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Indacaterol maleate

Indacaterol maleate
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
Catalog No. T1239Cas No. 753498-25-8
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Purity:99.67%
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Indacaterol maleate

Purity: 99.67%
Catalog No. T1239Alias QAB149Cas No. 753498-25-8

Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
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Pack SizePriceAvailabilityQuantity
10 mg$30In Stock
25 mg$48In Stock
50 mg$68In Stock
100 mg$98In Stock
200 mg$148In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
Targets&IC50
β1-adrenoceptor:7.36(pKi), β2-adrenoceptor:5.48(pKi)
In vitro
Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium. [1] Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways. [2] Indacaterol (10 μM) induces close to full inhibition of the EFS-induced contraction of isolated human bronchi and the effect lasts 12 hours. [3] Indacaterol inhibits the IgE-dependent release of histamine from mast cells with the intrinsic activity (Emax of a long-acting Indacaterol/Emax of Isoprenaline) of 1.03. [4] Indacaterol inihbits cAMP release from human airway smooth muscle with pEC50 of 8.53 and Emax of 48%. Indacaterol appears to have a reduced efficacy compared with the CHO-K1 data in the primary ASM cells. [5]
In vivo
Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey. [1]
AliasQAB149
Chemical Properties
Molecular Weight508.56
FormulaC28H32N2O7
Cas No.753498-25-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 94 mg/mL (184.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9663 mL9.8317 mL19.6634 mL98.3168 mL
5 mM0.3933 mL1.9663 mL3.9327 mL19.6634 mL
10 mM0.1966 mL0.9832 mL1.9663 mL9.8317 mL
20 mM0.0983 mL0.4916 mL0.9832 mL4.9158 mL
50 mM0.0393 mL0.1966 mL0.3933 mL1.9663 mL
100 mM0.0197 mL0.0983 mL0.1966 mL0.9832 mL

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